Video | The Mechanome
The Mechanome: The missing link between your genes and environment
The Mechanome is a field of study that relates to the mechanical forces experienced by cells and how they influence gene expression and cellular responses. It is a relatively new area of research that has broad implications for our understanding of health and disease. The mechanome is essentially the link between mechanics and biology.
Mechanotransduction is the process by which cells convert mechanical stimuli into biochemical signals. In other words, it is how cells sense and respond to mechanical forces. This process is essential for many cellular functions, including cell division, differentiation, and migration. Mechanotransduction plays a critical role in tissue development, repair, and regeneration.
Chronic Diseases and Mechanotransduction
Chronic diseases such as diabetes, heart disease, and cancer are increasingly recognized as mechanotransduction diseases. Mechanotransduction plays a critical role in the development and progression of these diseases. For example, obesity exerts mechanical forces on cells, leading to changes in gene expression that promote inflammation and insulin resistance, which can lead to type 2 diabetes. Similarly, the mechanical forces exerted on the heart by high blood pressure can lead to changes in gene expression that promote heart failure.
The Role of Chiropractic in the Mechanome
Chiropractic care has long been associated with the relief of musculoskeletal pain and dysfunction. However, recent research has shown that chiropractic adjustments can also influence mechanotransduction. Chiropractic adjustments stimulate mechanoreceptors in the joints and muscles, sending signals to the brain and spinal cord that can have a profound effect on gene expression and cellular responses.
At New Life Family Chiropractic Center, we recognize the importance of the Mechanome as a field of research that sheds light on the intricate connection between mechanics and biology. We believe that Mechanotransduction is a crucial factor in promoting health and preventing diseases, and our chiropractic care services aim to enhance this relationship for your optimal wellness. By leveraging our understanding of the mechanome, we can develop innovative approaches to disease prevention and treatment that account for the influence of mechanical forces. Please make an appointment with us today to learn more about how we can support your health journey.
- Wang, N., & Ingber, D. E. (1994). Control of cytoskeletal mechanics by extracellular matrix, cell shape, and mechanical tension. Biophysical journal, 66(6), 2181-2189.
- Discher, D. E., Janmey, P., & Wang, Y. L. (2005). Tissue cells feel and respond to the stiffness of their substrate. Science, 310(5751), 1139-1143.
- Humphrey, J. D., Dufresne, E. R., & Schwartz, M. A. (2014). Mechanotransduction and extracellular matrix homeostasis. Nature reviews Molecular cell biology, 15(12), 802-812.
- Wang, H. B., Dembo, M., & Wang, Y. L. (2000). Substrate flexibility regulates growth and apoptosis of normal but not transformed cells. American Journal of Physiology-Cell Physiology, 279(5), C1345-C1350.
- Schwartz, M. A., & Assoian, R. K. (2001). Integrins and cell proliferation: regulating the cyclin D1 gene. The Journal of cell biology, 157(4), 447-451.
- Cross, S. E., Jin, Y. S., Rao, J., & Gimzewski, J. K. (2007). Nanomechanical analysis of cells from cancer patients. Nature nanotechnology, 2(12), 780-783.
- Wang, D. D., Bordeleau, F., Xin, L., & Sheetz, M. P. (2019). Mammalian cells respond to nanoscale surface curvature. Nano letters, 19(10), 6888-6895.
- Raimondi, M. T., Boschetti, F., Falcone, P., & Pietrabissa, R. (2004). Mechanobiology of cells and tissues. Biomechanics and modeling in mechanobiology, 1(3), 145-155.
- Adams, J. C., & Schwartz, M. A. (2000). Stimulation of fascia adhesion protein expression by mechanical loading is localized and dependent on the cytoskeleton. Journal of cell science, 113(23), 4267-4278.
- Bagnéris, C., Rajan, R., Tartaglia, G. G., & Cohen, S. (2019). Structural principles of mechanosensing. Developmental cell, 49(2), 169-180.
You may also like:
Gut Health Chiropractor: Why Vagus Nerve Stimulation Matters http...
4 natural ways to fix plantar fasciitis.
Sleep Switch and Chiropractic. How to Help Sleep Disorders Natura...
Chiropractic Approach for Painful Menses: A Natural and Holistic ...
Back Pain and The Chiropractic Approach. Among people seeking bac...
Baby Curve Development and Movement Infant spinal curve developme...
Autism, Poly-Vagal theory!Video for the therapists and parents ...
Discover how chiropractic care offers a safe and effective altern...
The Movement Paradox: From DNA to Embryogenesis to Mitochondria. ...